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Michiaki Mishima Selected Research

OSI-420

9/2011Plasma and pleural fluid pharmacokinetics of erlotinib and its active metabolite OSI-420 in patients with non-small-cell lung cancer with pleural effusion.
7/2010Cerebrospinal fluid concentration of erlotinib and its active metabolite OSI-420 in patients with central nervous system metastases of non-small cell lung cancer.
5/2010Pharmacokinetics of erlotinib and its active metabolite OSI-420 in patients with non-small cell lung cancer and chronic renal failure who are undergoing hemodialysis.

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Michiaki Mishima Research Topics

Disease

49Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
07/2016 - 06/2006
48Asthma (Bronchial Asthma)
11/2023 - 12/2002
36Chronic Obstructive Pulmonary Disease (COPD)
01/2019 - 12/2002
24Neoplasms (Cancer)
01/2019 - 10/2004
22Inflammation (Inflammations)
10/2018 - 04/2004
18Interstitial Lung Diseases (Interstitial Lung Disease)
03/2019 - 01/2007
15Cough
04/2023 - 04/2007
15Obstructive Sleep Apnea
01/2017 - 04/2003
12Dyspnea (Shortness of Breath)
01/2017 - 09/2002
11Neoplasm Metastasis (Metastasis)
01/2019 - 03/2010
11Pneumonia (Pneumonitis)
11/2016 - 10/2002
10Small Cell Lung Carcinoma (Small Cell Lung Cancer)
01/2017 - 07/2009
10Lung Neoplasms (Lung Cancer)
11/2015 - 03/2006
7Airway Remodeling
01/2019 - 03/2008
7Idiopathic Pulmonary Fibrosis
07/2017 - 12/2009
7Disease Progression
11/2016 - 12/2009
7Emphysema
09/2015 - 12/2005
7Fibrosis (Cirrhosis)
07/2015 - 03/2004
7Pulmonary Fibrosis (Fibrosing Alveolitis)
02/2013 - 03/2004
6Hypoxia (Hypoxemia)
07/2023 - 02/2005
6Lung Diseases (Lung Disease)
06/2021 - 01/2003
6Lymphangioleiomyomatosis (Lymphangiomyomatosis)
10/2017 - 02/2011
6Sleepiness
01/2017 - 05/2004
6Apnea
01/2016 - 06/2004
6Adenocarcinoma of Lung
01/2013 - 10/2007
5Gastroesophageal Reflux (GERD)
01/2017 - 07/2008
5Sleep Apnea Syndromes (Sleep Apnea)
01/2016 - 03/2004
5Infections
01/2016 - 05/2007
5Brain Neoplasms (Brain Tumor)
08/2015 - 04/2010
5Fever (Fevers)
05/2013 - 10/2002
4Myositis (Idiopathic Inflammatory Myopathies)
07/2021 - 01/2014
4Dermatomyositis (Dermatopolymyositis)
03/2019 - 01/2016
4Chronic Cough
01/2019 - 03/2009
4Sarcoidosis (Schaumann Disease)
01/2019 - 01/2003
4Respiratory Insufficiency (Respiratory Failure)
03/2017 - 01/2010
4Cardiovascular Diseases (Cardiovascular Disease)
01/2015 - 01/2013
4Cough-Variant Asthma
01/2012 - 03/2006
4Lung Injury
06/2011 - 03/2006
4Respiratory Sounds (Crackle)
04/2009 - 03/2006
3Hypersensitivity (Allergy)
04/2023 - 12/2008
3Squamous Cell Carcinoma (Epidermoid Carcinoma)
10/2022 - 08/2012
3Body Weight (Weight, Body)
10/2018 - 03/2012
3Immunoglobulin G4-Related Disease
09/2018 - 02/2012
3Stomatitis
10/2017 - 10/2011
3Idiopathic Interstitial Pneumonias
01/2017 - 01/2007
3Adenocarcinoma
01/2017 - 01/2009

Drug/Important Bio-Agent (IBA)

26Adrenal Cortex Hormones (Corticosteroids)IBA
11/2023 - 07/2003
22ErbB Receptors (EGF Receptor)IBA
01/2017 - 10/2006
16Erlotinib Hydrochloride (CP 358,774)FDA Link
07/2013 - 04/2010
15Nitric Oxide (Nitrogen Monoxide)FDA Link
11/2019 - 04/2008
15Biomarkers (Surrogate Marker)IBA
01/2019 - 11/2008
12Gefitinib (Iressa)FDA Link
09/2012 - 01/2007
9Oxygen (Dioxygen)IBA
07/2023 - 09/2002
9Tyrosine Kinase InhibitorsIBA
01/2017 - 10/2008
9SteroidsIBA
09/2015 - 01/2003
7Proteins (Proteins, Gene)FDA Link
11/2015 - 12/2005
7Pemetrexed (MTA)FDA Link
03/2015 - 03/2011
7SmokeIBA
05/2014 - 10/2007
7Bronchodilator Agents (Bronchodilators)IBA
08/2012 - 06/2003
6AutoantibodiesIBA
07/2021 - 08/2011
6Immunoglobulin E (IgE)IBA
09/2018 - 04/2009
6CollagenIBA
05/2015 - 12/2006
6PlatinumIBA
05/2015 - 07/2009
6Methacholine Chloride (Methacholine)FDA Link
10/2014 - 11/2006
6CytokinesIBA
05/2013 - 03/2006
5C-Reactive ProteinIBA
10/2018 - 01/2010
5Interleukin-6 (Interleukin 6)IBA
10/2018 - 03/2006
5PeriostinIBA
02/2017 - 08/2013
5Carbon MonoxideIBA
01/2017 - 11/2003
5lipoarabinomannan (LAM)IBA
11/2016 - 02/2011
5Bevacizumab (Avastin)FDA Link
08/2015 - 07/2010
5Messenger RNA (mRNA)IBA
05/2014 - 10/2007
5Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
09/2013 - 07/2007
5Bleomycin (Blenoxane)FDA LinkGeneric
01/2013 - 03/2004
5ThioredoxinsIBA
01/2013 - 01/2007
5Epidermal Growth Factor (EGF)IBA
09/2012 - 04/2010
5Capsaicin (Zostrix)FDA Link
01/2012 - 04/2007
4GlucocorticoidsIBA
09/2018 - 10/2011
4Immunoglobulin G (IgG)IBA
09/2018 - 01/2012
4ProstaglandinsIBA
01/2017 - 12/2009
4AntibodiesIBA
01/2017 - 08/2011
4Glucose (Dextrose)FDA LinkGeneric
01/2016 - 08/2012
4Phosphotransferases (Kinase)IBA
02/2015 - 04/2010
4Triglycerides (Triacylglycerol)IBA
01/2015 - 04/2003
4AllergensIBA
11/2014 - 10/2007
3Omalizumab (Xolair)FDA Link
04/2023 - 05/2013
3Carboplatin (JM8)FDA LinkGeneric
10/2022 - 08/2012
3Paclitaxel (Taxol)FDA LinkGeneric
10/2022 - 01/2015
3Matrix Metalloproteinases (MMPs)IBA
03/2019 - 04/2004
3Tiotropium Bromide (Spiriva)FDA Link
01/2018 - 02/2010

Therapy/Procedure

35Therapeutics
01/2022 - 04/2003
24Drug Therapy (Chemotherapy)
10/2022 - 06/2003
10Continuous Positive Airway Pressure
01/2017 - 04/2003
7Noninvasive Ventilation
11/2017 - 05/2005
6Aftercare (After-Treatment)
08/2015 - 04/2003
5Radiotherapy
01/2015 - 03/2006
4Liver Transplantation
02/2011 - 02/2005
4Positive-Pressure Respiration (Positive End-Expiratory Pressure)
01/2011 - 11/2004
3Chemoradiotherapy
01/2019 - 06/2006
3Artificial Respiration (Mechanical Ventilation)
01/2019 - 11/2004